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UniProt functional annotation for P23582 | ||
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| UniProt code: P23582. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
[CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490). {ECO:0000250|UniProtKB:Q61839, ECO:0000269|PubMed:11533490, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:21098034}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
[CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level). {ECO:0000269|PubMed:9794555}. |
| Ptm: | |
[CNP-22]: Degraded by IDE (in vitro). {ECO:0000269|PubMed:21098034}. |
| Similarity: | |
Belongs to the natriuretic peptide family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.