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UniProt functional annotation for P17342 | ||
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| UniProt code: P17342. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. {ECO:0000250|UniProtKB:P70180}. |
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| Subunit: | |
Homodimer; disulfide-linked (PubMed:11533490). Dimers can also be formed through the C-terminal cysteine of isoform 2 (PubMed:11533490). Interacts with OSTN (By similarity). {ECO:0000250|UniProtKB:P70180, ECO:0000269|PubMed:11533490}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Miscellaneous: | |
Has low affinity for peptide hormones in the absence of bound chloride. |
| Similarity: | |
Belongs to the ANF receptor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.