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UniProt functional annotation for Q02293 | ||
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| UniProt code: Q02293. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}. |
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| Catalytic activity: | |
Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; EC=2.5.1.58; Evidence={ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}; |
| Subunit: | |
Heterodimer of FNTA and FNTB. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9065406, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}. |
| Similarity: | |
Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.