UniProt functional annotation for P61972



	UniProt functional annotation for P61972

UniProt code: P61972.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:9822603}.

Subunit: Homodimer (PubMed:8757804, PubMed:9533885, PubMed:11846560, PubMed:15522285). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:9822603, PubMed:8757804, PubMed:9368653, PubMed:9533885, PubMed:11846560, PubMed:15522285). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:8707840, PubMed:9368653, PubMed:10543952, PubMed:11846560, PubMed:15522285). Interacts with CAPG; mediates its nuclear import (By similarity). {ECO:0000250|UniProtKB:P61970, ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560, ECO:0000269|PubMed:15522285, ECO:0000269|PubMed:8707840, ECO:0000269|PubMed:8757804, ECO:0000269|PubMed:9368653, ECO:0000269|PubMed:9533885, ECO:0000269|PubMed:9822603}.

Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:9822603}. Nucleus outer membrane {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560, ECO:0000269|PubMed:15522285, ECO:0000269|PubMed:9822603}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560, ECO:0000269|PubMed:15522285}. Nucleus inner membrane {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P61970}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000250|UniProtKB:P61970}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269\|PubMed:10543952, ECO:0000269\|PubMed:9822603}.


Subunit:		Homodimer (PubMed:8757804, PubMed:9533885, PubMed:11846560, PubMed:15522285). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:9822603, PubMed:8757804, PubMed:9368653, PubMed:9533885, PubMed:11846560, PubMed:15522285). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:8707840, PubMed:9368653, PubMed:10543952, PubMed:11846560, PubMed:15522285). Interacts with CAPG; mediates its nuclear import (By similarity). {ECO:0000250\|UniProtKB:P61970, ECO:0000269\|PubMed:10543952, ECO:0000269\|PubMed:11846560, ECO:0000269\|PubMed:15522285, ECO:0000269\|PubMed:8707840, ECO:0000269\|PubMed:8757804, ECO:0000269\|PubMed:9368653, ECO:0000269\|PubMed:9533885, ECO:0000269\|PubMed:9822603}.
Subcellular location:		Cytoplasm, cytosol {ECO:0000269\|PubMed:9822603}. Nucleus outer membrane {ECO:0000269\|PubMed:10543952, ECO:0000269\|PubMed:11846560, ECO:0000269\|PubMed:15522285, ECO:0000269\|PubMed:9822603}. Nucleus, nuclear pore complex {ECO:0000269\|PubMed:10543952, ECO:0000269\|PubMed:11846560, ECO:0000269\|PubMed:15522285}. Nucleus inner membrane {ECO:0000269\|PubMed:10543952, ECO:0000269\|PubMed:11846560}. Nucleus, nucleoplasm {ECO:0000250\|UniProtKB:P61970}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000250\|UniProtKB:P61970}.