UniProt functional annotation for Q7SZI7



	UniProt functional annotation for Q7SZI7

UniProt code: Q7SZI7.

Organism: Xenopus laevis (African clawed frog).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.

Function: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Also involved in the transport of fatty acids and retinal development.

Subunit: Monomer. Interacts with retinol. Predominantly found as a monomer, but to a really lower extent also found as a homodimer. {ECO:0000269|PubMed:11796109, ECO:0000269|PubMed:18079675}.

Subcellular location: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Cytoplasm. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells. Lesser amounts found in the pigment epithelial cytoplasm.

Tissue specificity: Expressed in retina; at similar levels by both cones and rods. Weakly expressed in brain. In embryos, expression is restricted to the central retina. {ECO:0000269|PubMed:8360278, ECO:0000269|PubMed:8698895}.

Developmental stage: Expressed in retina at stage 42. In swimming tadpole, expression begins from stage 40, is clearly visible at stage 43 and increased markedly by stage 45/46. Expression appears to be restricted to the head. {ECO:0000269|PubMed:8360278, ECO:0000269|PubMed:8698895}.

Ptm: Glycosylated. {ECO:0000305|PubMed:8360278}.

Similarity: Belongs to the peptidase S41A family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Xenopus laevis (African clawed frog).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.



Function:		IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Also involved in the transport of fatty acids and retinal development.


Subunit:		Monomer. Interacts with retinol. Predominantly found as a monomer, but to a really lower extent also found as a homodimer. {ECO:0000269\|PubMed:11796109, ECO:0000269\|PubMed:18079675}.
Subcellular location:		Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Cytoplasm. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells. Lesser amounts found in the pigment epithelial cytoplasm.
Tissue specificity:		Expressed in retina; at similar levels by both cones and rods. Weakly expressed in brain. In embryos, expression is restricted to the central retina. {ECO:0000269\|PubMed:8360278, ECO:0000269\|PubMed:8698895}.
Developmental stage:		Expressed in retina at stage 42. In swimming tadpole, expression begins from stage 40, is clearly visible at stage 43 and increased markedly by stage 45/46. Expression appears to be restricted to the head. {ECO:0000269\|PubMed:8360278, ECO:0000269\|PubMed:8698895}.
Ptm:		Glycosylated. {ECO:0000305\|PubMed:8360278}.
Similarity:		Belongs to the peptidase S41A family. {ECO:0000305}.