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UniProt functional annotation for P0A3R9 | ||
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| UniProt code: P0A3R9. |
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| Organism: | |
Streptomyces carzinostaticus. |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. |
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| Similarity: | |
Belongs to the neocarzinostatin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.