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UniProt functional annotation for Q45697 | ||
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| UniProt code: Q45697. |
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| Organism: | |
Bacillus sp. (strain TB-90). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5- carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301, ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526, ChEBI:CHEBI:58639; EC=4.1.1.97; |
| Catalytic activity: | |
Reaction=H2O + O2 + urate = 5-hydroxyisourate + H2O2; Xref=Rhea:RHEA:21368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17775, ChEBI:CHEBI:18072; EC=1.7.3.3; |
| Pathway: | |
Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. |
| Pathway: | |
Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. |
| Miscellaneous: | |
HIU and OHCU are unstable, they spontaneously decompose to form a racemic mixture of allantoin. |
| Similarity: | |
In the N-terminal section; belongs to the OHCU decarboxylase family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the uricase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA08723.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.