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UniProt functional annotation for P70552 | ||
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| UniProt code: P70552. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
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| Subunit: | |
Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers. Interacts with GCH1. {ECO:0000269|PubMed:11818540, ECO:0000269|PubMed:9092499}. |
| Subcellular location: | |
Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
| Tissue specificity: | |
Liver and kidney. Somewhat lower level in testis, heart, brain and lung. |
| Similarity: | |
Belongs to the GFRP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.