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UniProt functional annotation for P10646 | ||
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| UniProt code: P10646. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
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| Subcellular location: | |
[Isoform Alpha]: Secreted. |
| Subcellular location: | |
[Isoform Beta]: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}. |
| Tissue specificity: | |
Mostly in endothelial cells. |
| Domain: | |
This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa. |
| Ptm: | |
O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19017259, ECO:0000269|PubMed:8639592}. |
| Miscellaneous: | |
[Isoform Beta]: GPI-anchored. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.