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UniProt functional annotation for O74035 | ||
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| UniProt code: O74035. |
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| Organism: | |
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)). |
| Taxonomy: | |
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus. |
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| Function: | |
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. {ECO:0000250}; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Similarity: | |
Belongs to the RNase HII family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.