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UniProt functional annotation for P09713 | ||
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| UniProt code: P09713. |
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| Organism: | |
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. |
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| Function: | |
Participates in the inhibition of the host immune response. Early protein that redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction (PubMed:19121997). In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM. {ECO:0000269|PubMed:16098592, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:8945469}. |
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| Subunit: | |
Monomer (Probable). Interacts with host TRAM1 (PubMed:19121997). {ECO:0000269|PubMed:19121997, ECO:0000305}. |
| Subcellular location: | |
Host endoplasmic reticulum membrane {ECO:0000269|PubMed:11790769}; Single-pass type I membrane protein {ECO:0000269|PubMed:11790769}. |
| Developmental stage: | |
Expressed at early period of virus infection. |
| Domain: | |
The lumenal domain allows tight interaction with class I molecules encoded by the HLA-A locus. |
| Ptm: | |
The signal sequence is not cleaved. |
| Similarity: | |
Belongs to the cytomegalovirus US2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.