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PDBsum entry 1idc
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Oxidoreductase (NAD(a)-choh(d))
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PDB id
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1idc
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References listed in PDB file
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Key reference
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Title
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Mutagenesis and laue structures of enzyme intermediates: isocitrate dehydrogenase.
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Authors
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J.M.Bolduc,
D.H.Dyer,
W.G.Scott,
P.Singer,
R.M.Sweet,
D.E.Koshland,
B.L.Stoddard.
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Ref.
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Science, 1995,
268,
1312-1318.
[DOI no: ]
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PubMed id
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Abstract
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Site-directed mutagenesis and Laue diffraction data to 2.5 A resolution were
used to solve the structures of two sequential intermediates formed during the
catalytic actions of isocitrate dehydrogenase. Both intermediates are distinct
from the enzyme-substrate and enzyme-product complexes. Mutation of key
catalytic residues changed the rate determining steps so that protein and
substrate intermediates within the overall reaction pathway could be visualized.
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Secondary reference #1
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Title
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Catalytic mechanism of NADP(+)-Dependent isocitrate dehydrogenase: implications from the structures of magnesium-Isocitrate and NADP+ complexes.
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Authors
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J.H.Hurley,
A.M.Dean,
D.E.Koshland,
R.M.Stroud.
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Ref.
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Biochemistry, 1991,
30,
8671-8678.
[DOI no: ]
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PubMed id
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Secondary reference #2
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Title
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Regulation of isocitrate dehydrogenase by phosphorylation involves no long-Range conformational change in the free enzyme.
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Authors
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J.H.Hurley,
A.M.Dean,
P.E.Thorsness,
D.E.Koshland,
R.M.Stroud.
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Ref.
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J Biol Chem, 1990,
265,
3599-3602.
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PubMed id
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Secondary reference #3
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Title
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Regulation of an enzyme by phosphorylation at the active site.
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Authors
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J.H.Hurley,
A.M.Dean,
J.L.Sohl,
D.E.Koshland,
R.M.Stroud.
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Ref.
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Science, 1990,
249,
1012-1016.
[DOI no: ]
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PubMed id
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Secondary reference #4
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Title
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Structure of a bacterial enzyme regulated by phosphorylation, Isocitrate dehydrogenase.
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Authors
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J.H.Hurley,
P.E.Thorsness,
V.Ramalingam,
N.H.Helmers,
D.E.Koshland,
R.M.Stroud.
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Ref.
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Proc Natl Acad Sci U S A, 1989,
86,
8635-8639.
[DOI no: ]
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PubMed id
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