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UniProt functional annotation for P28305 | ||
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| UniProt code: P28305. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate. {ECO:0000269|PubMed:1644759, ECO:0000269|PubMed:2251281}. |
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| Catalytic activity: | |
Reaction=4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate; Xref=Rhea:RHEA:16201, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:17836, ChEBI:CHEBI:58406; EC=4.1.3.38; Evidence={ECO:0000269|PubMed:2251281}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:10876155, ECO:0000269|PubMed:11841211, ECO:0000269|PubMed:1644759}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate: step 2/2. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10876155, ECO:0000269|PubMed:11841211, ECO:0000269|PubMed:1644759, ECO:0000269|PubMed:2251281}. |
| Disruption phenotype: | |
Cells lacking this gene are unable to produce PABA. {ECO:0000269|PubMed:1644759}. |
| Similarity: | |
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.