|
|
||
|
|
|
|
|
UniProt functional annotation for P00338 | ||
|
|
|
|
|
|
||
| UniProt code: P00338. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
| Catalytic activity: | |
Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; |
| Pathway: | |
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. |
| Subunit: | |
Homotetramer (PubMed:11276087). Interacts with PTEN upstream reading frame protein MP31 (PubMed:33406399). {ECO:0000269|PubMed:11276087, ECO:0000269|PubMed:33406399}. |
| Subcellular location: | |
Cytoplasm. |
| Ptm: | |
ISGylated. {ECO:0000269|PubMed:16139798}. |
| Disease: | |
Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269|PubMed:2334430}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the LDH/MDH superfamily. LDH family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.