|
|
||
|
|
|
|
|
UniProt functional annotation for Q02853 | ||
|
|
|
|
|
|
||
| UniProt code: Q02853. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
May play an important role in the progression of epithelial malignancies. |
|
||
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| Subcellular location: | |
Secreted, extracellular space, extracellular matrix {ECO:0000305}. |
| Tissue specificity: | |
Specifically expressed in the mammary gland during apoptosis. |
| Domain: | |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation- peptide release activates the enzyme. |
| Ptm: | |
The precursor is cleaved by a furin endopeptidase. {ECO:0000250}. |
| Similarity: | |
Belongs to the peptidase M10A family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.