UniProt functional annotation for P11568

UniProt code: P11568.

Organism:		Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4).
Taxonomy:		Bacteria; Firmicutes; Negativicutes; Acidaminococcales; Acidaminococcaceae; Acidaminococcus.
Function:		Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional. {ECO:0000269|PubMed:7607244, ECO:0000305|PubMed:3691501}.
Catalytic activity:		Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000305|PubMed:3691501, ECO:0000305|PubMed:7607244};
Cofactor:		Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:11106419, ECO:0000269|PubMed:11243821, ECO:0000269|PubMed:7607244}; Note=Binds 1 [4Fe-4S] cluster per dimer. {ECO:0000269|PubMed:11106419, ECO:0000269|PubMed:11243821, ECO:0000269|PubMed:7607244};
Cofactor:		Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11106419, ECO:0000269|PubMed:11243821, ECO:0000305|PubMed:7607244};
Activity regulation:		Inactivated by exposure to air within less than 15 minutes. {ECO:0000269|PubMed:3691501}.
Pathway:		Amino-acid degradation; L-glutamate degradation via hydroxyglutarate pathway; crotonoyl-CoA from L-glutamate: step 4/5. {ECO:0000305|PubMed:7607244}.
Subunit:		Homodimer. {ECO:0000269|PubMed:11243821, ECO:0000269|PubMed:3691501, ECO:0000269|PubMed:7607244}.
Miscellaneous:		HgdC (CompA) seems to require NADH to be functional. {ECO:0000305|PubMed:3691501}.
Similarity:		Belongs to the HgdC family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.