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UniProt functional annotation for P9WIU7 | ||
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| UniProt code: P9WIU7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host (PubMed:12637582). {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:12637582, ECO:0000305}. |
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| Catalytic activity: | |
Reaction=H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine; Xref=Rhea:RHEA:15101, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32551, ChEBI:CHEBI:57791; EC=4.1.1.20; Evidence={ECO:0000255|HAMAP-Rule:MF_02120}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:12637582}; |
| Pathway: | |
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_02120}. |
| Subunit: | |
Homodimer; disulfide-linked. Can also form homotetramer at higher protein concentrations. {ECO:0000269|PubMed:12637582, ECO:0000269|PubMed:16511157, ECO:0000269|PubMed:19543810}. |
| Disruption phenotype: | |
Strains lacking this gene are lysine auxotrophs. They cannot survive in immunocompromised mice. {ECO:0000269|PubMed:12637582}. |
| Miscellaneous: | |
Was identified as a high-confidence drug target. {ECO:0000305|PubMed:19099550}. |
| Similarity: | |
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. {ECO:0000255|HAMAP-Rule:MF_02120}. |
Annotations taken from UniProtKB at the EBI.