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UniProt functional annotation for P06608 | ||
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| UniProt code: P06608. |
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| Organism: | |
Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Pectobacteriaceae; Dickeya. |
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| Catalytic activity: | |
Reaction=H2O + L-asparagine = L-aspartate + NH4(+); Xref=Rhea:RHEA:21016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:58048; EC=3.5.1.1; |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:11755201, ECO:0000269|PubMed:12499544, ECO:0000269|PubMed:8348975}. |
| Pharmaceutical: | |
Available under the name Erwinase (Beaufour Ipsen). Used as an antineoplastic in chemotherapy. Reduces the quantity of asparagine available to cancer cells. |
| Miscellaneous: | |
The sequence of strain NCPPB 1066 is shown. |
| Similarity: | |
Belongs to the asparaginase 1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.