 |
PDBsum entry 1ha1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nuclear protein
|
PDB id
|
|
|
|
1ha1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Crystal structure of the two RNA binding domains of human hnrnp a1 at 1.75 a resolution.
|
|
|
Authors
|
|
Y.Shamoo,
U.Krueger,
L.M.Rice,
K.R.Williams,
T.A.Steitz.
|
|
|
Ref.
|
|
Nat Struct Biol, 1997,
4,
215-222.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear
RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP
particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may
modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two
independently-folded RNA binding domains (RBDs) connected by a flexible linker.
Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA
binding platforms oriented in an anti-parallel fashion. The anti-parallel
arrangement of the A1 RNA binding platforms suggests mechanisms for RNA
condensation and ways of bringing together distant RNA sequences for RNA
metabolism such as splicing or transport.
|
|
|
Secondary reference #1
|
|
|
Title
|
|
Determination of the secondary structure and folding topology of an RNA binding domain of mammalian hnrnp a1 protein using three-Dimensional heteronuclear magnetic resonance spectroscopy.
|
|
|
Authors
|
|
D.S.Garrett,
P.J.Lodi,
Y.Shamoo,
K.R.Williams,
G.M.Clore,
A.M.Gronenborn.
|
|
|
Ref.
|
|
Biochemistry, 1994,
33,
2852-2858.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
|
|
|
|
|
|
|
