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UniProt functional annotation for Q28943 | ||
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| UniProt code: Q28943. |
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| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
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| Function: | |
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. {ECO:0000269|PubMed:11179210, ECO:0000269|PubMed:20831907, ECO:0000269|PubMed:9860876}. |
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| Catalytic activity: | |
Reaction=5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil; Xref=Rhea:RHEA:18093, ChEBI:CHEBI:15378, ChEBI:CHEBI:15901, ChEBI:CHEBI:17568, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.2; Evidence={ECO:0000269|PubMed:20831907, ECO:0000269|PubMed:9860876}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Cofactor: | |
Name=FMN; Xref=ChEBI:CHEBI:58210; |
| Pathway: | |
Amino-acid biosynthesis; beta-alanine biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11179210, ECO:0000269|PubMed:11796730, ECO:0000269|PubMed:9860876}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the dihydropyrimidine dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.