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UniProt functional annotation for P00698 | ||
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| UniProt code: P00698. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. {ECO:0000255|PROSITE-ProRule:PRU00680, ECO:0000269|PubMed:22044478}. |
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| Catalytic activity: | |
Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
In the egg white and polymorphonuclear leukocytes. |
| Polymorphism: | |
Numerous polymorphisms have been identified in various strains, predominantly at positions 49 and 71 (PubMed:19845599). The sequence shown here is that of red jungle fowl (PubMed:15592404). {ECO:0000269|PubMed:15592404, ECO:0000269|PubMed:19845599}. |
| Allergen: | |
Causes an allergic reaction in human. |
| Miscellaneous: | |
Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides. |
| Similarity: | |
Belongs to the glycosyl hydrolase 22 family. {ECO:0000255|PROSITE-ProRule:PRU00680}. |
Annotations taken from UniProtKB at the EBI.