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UniProt functional annotation for P06983 | ||
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| UniProt code: P06983. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. {ECO:0000269|PubMed:3529035}. |
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| Catalytic activity: | |
Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61; |
| Cofactor: | |
Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Note=Binds 1 dipyrromethane group covalently.; |
| Pathway: | |
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:3529035}. |
| Miscellaneous: | |
Arginine residues that are closely associated with one another might be involved in substrate binding. |
| Miscellaneous: | |
The porphobilinogen subunits are added to the dipyrromethane group. |
| Similarity: | |
Belongs to the HMBS family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA67601.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.