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UniProt functional annotation for Q7SIC2 | ||
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| UniProt code: Q7SIC2. |
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| Organism: | |
Aspergillus japonicus. |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. |
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| Function: | |
Performs the first step in the degradation of the flavonoid quercetin by a dioxygenase reaction. The enzyme catalyzes the cleavage of the O-heteroaromatic ring of the flavonol quercetin yielding the depside 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. This involves the remarkable dioxygenolytic cleavage of two carbon-carbon bonds. |
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| Catalytic activity: | |
Reaction=O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6- dihydroxybenzoate + CO; Xref=Rhea:RHEA:15381, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:57628, ChEBI:CHEBI:57694; EC=1.13.11.24; |
| Cofactor: | |
Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.; |
| Activity regulation: | |
Inhibited by diethyldithiocarbamate and kojic acid. |
| Pathway: | |
Flavonoid metabolism; quercetin degradation. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:12069585, ECO:0000269|PubMed:12486225}. |
| Ptm: | |
The N-linked glycan at Asn-191 consists of Man(5)-GlcNAc(2). |
Annotations taken from UniProtKB at the EBI.