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UniProt functional annotation for P02741 | ||
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| UniProt code: P02741. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
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| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.; |
| Subunit: | |
Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1. {ECO:0000269|PubMed:21037097}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Found in plasma. |
| Induction: | |
The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6. |
| Mass spectrometry: | |
[C-reactive protein]: Mass=23028; Method=MALDI; Evidence={ECO:0000269|Ref.15}; |
| Mass spectrometry: | |
[C-reactive protein(1-205)]: Mass=22930; Method=MALDI; Evidence={ECO:0000269|Ref.15}; |
| Miscellaneous: | |
This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. |
| Similarity: | |
Belongs to the pentraxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.