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PDBsum entry 1gnh
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Acute-phase protein
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PDB id
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1gnh
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Three dimensional structure of human c-Reactive protein.
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Authors
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A.K.Shrive,
G.M.Cheetham,
D.Holden,
D.A.Myles,
W.G.Turnell,
J.E.Volanakis,
M.B.Pepys,
A.C.Bloomer,
T.J.Greenhough.
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Ref.
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Nat Struct Biol, 1996,
3,
346-354.
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PubMed id
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Abstract
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The structure of the classical acute phase reactant human C-reactive protein
provides evidence that phosphocholine binding is mediated through calcium and a
hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned
to interact with the choline group. A cleft on the pentameric face opposite to
that containing the calcium site may have an important functional role. The
structure provides insights into the molecular mechanisms by which this highly
conserved plasma protein, for which no polymorphism or deficiency state is
known, may exert its biological role.
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