|
|
||
|
|
|
|
|
UniProt functional annotation for Q9Y258 | ||
|
|
|
|
|
|
||
| UniProt code: Q9Y258. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis (PubMed:20974991). {ECO:0000269|PubMed:10415065, ECO:0000269|PubMed:10488147, ECO:0000269|PubMed:11425309, ECO:0000269|PubMed:20974991}. |
|
||
| Subunit: | |
Monomer. {ECO:0000269|PubMed:10488147}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:10488147}. |
| Tissue specificity: | |
Ubiquitously expressed at low levels in various tissues including heart and ovary. {ECO:0000269|PubMed:10373330, ECO:0000269|PubMed:10488147}. |
| Similarity: | |
Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.