UniProt functional annotation for P18798



	UniProt functional annotation for P18798

UniProt code: P18798.

Organism: Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales; Methylococcaceae; Methylococcus.

Function: Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.

Catalytic activity: Reaction=H(+) + methane + NADH + O2 = H2O + methanol + NAD(+); Xref=Rhea:RHEA:13637, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16183, ChEBI:CHEBI:17790, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.14.13.25;

Catalytic activity: Reaction=H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+); Xref=Rhea:RHEA:13641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16183, ChEBI:CHEBI:17790, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.25;

Subunit: M.capsulatus has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.

Annotations taken from UniProtKB at the EBI.


Organism:		Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales; Methylococcaceae; Methylococcus.



Function:		Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.


Catalytic activity:		Reaction=H(+) + methane + NADH + O2 = H2O + methanol + NAD(+); Xref=Rhea:RHEA:13637, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16183, ChEBI:CHEBI:17790, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.14.13.25;
Catalytic activity:		Reaction=H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+); Xref=Rhea:RHEA:13641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16183, ChEBI:CHEBI:17790, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.25;
Subunit:		M.capsulatus has two forms of methane monooxygenase, a soluble and a membrane-bound type. The soluble type consists of four components (A to D): protein A, comprising three chains, in an alpha-2, beta-2, gamma-2 configuration, is a nonheme iron protein containing an unusual mu-hydroxo bridge structure at its active site and interacts with both oxygen and methane.