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UniProt functional annotation for P54149 | ||
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| UniProt code: P54149. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. |
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| Catalytic activity: | |
Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]; Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120, ChEBI:CHEBI:50058; EC=1.8.4.11; Evidence={ECO:0000250|UniProtKB:Q9D6Y7}; |
| Catalytic activity: | |
Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58772; EC=1.8.4.11; Evidence={ECO:0000250|UniProtKB:Q9D6Y7}; |
| Subcellular location: | |
Mitochondrion {ECO:0000250}. |
| Similarity: | |
Belongs to the MsrA Met sulfoxide reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.