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UniProt functional annotation for P44492 | ||
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| UniProt code: P44492. |
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| Organism: | |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus. |
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| Function: | |
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro. {ECO:0000250, ECO:0000269|PubMed:12112691}. |
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| Biophysicochemical properties: | |
Kinetic parameters: KM=38 uM for ATP {ECO:0000269|PubMed:12112691}; Note=kcat is 0.42 min(-1) for ATP hydrolysis.; |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the TsaE family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.