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UniProt functional annotation for P20004 | ||
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| UniProt code: P20004. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. {ECO:0000250|UniProtKB:P19414}. |
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| Catalytic activity: | |
Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336, ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3; Evidence={ECO:0000250|UniProtKB:P19414}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:1547214}; Note=Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme. {ECO:0000269|PubMed:1547214}; |
| Pathway: | |
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. {ECO:0000250|UniProtKB:P19414}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:1547214}. |
| Subcellular location: | |
Mitochondrion {ECO:0000255}. |
| Ptm: | |
Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers. {ECO:0000250|UniProtKB:Q9ER34}. |
| Similarity: | |
Belongs to the aconitase/IPM isomerase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.