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UniProt functional annotation for P39040 | ||
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| UniProt code: P39040. |
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| Organism: | |
Crithidia fasciculata. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Leishmaniinae; Crithidia. |
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| Function: | |
Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase. |
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| Catalytic activity: | |
Reaction=NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide; Xref=Rhea:RHEA:16757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58290, ChEBI:CHEBI:58349, ChEBI:CHEBI:58661; EC=1.8.1.12; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 7.5-8.0.; |
| Subunit: | |
Homodimer. |
| Subcellular location: | |
Cytoplasm. |
| Ptm: | |
The N-terminus is blocked. |
| Miscellaneous: | |
The active site is a redox-active disulfide bond. |
| Similarity: | |
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.