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UniProt functional annotation for Q08169 | ||
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| UniProt code: Q08169. |
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| Organism: | |
Apis mellifera (Honeybee). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae; Apis. |
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| Function: | |
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides. {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; |
| Subunit: | |
Homotetramer. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed in the venom glands of worker bees. It is also detected in the testes of drones but not in the queen-bee venom glands or in pupae. |
| Ptm: | |
N-glycosylated. Glycans found include a majority of small oligosaccharides (Man1-3GlcNAc2), most of which are either alpha 1,3- monofucosylated or alpha 1,3-(alpha 1,6-)difucosylated at the innermost GlcNAc residue, approximately 5% of high-mannose type structures, and 8% contains the terminal trisaccharide GalNAc beta 1-4[Fuc alpha 1- 3]GlcNAc beta 1-in beta 1,2-linkage to the core alpha 1,3-mannosyl residue. {ECO:0000269|PubMed:10998264, ECO:0000269|PubMed:7795417}. |
| Allergen: | |
Causes an allergic reaction in human. |
| Similarity: | |
Belongs to the glycosyl hydrolase 56 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.