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UniProt functional annotation for P84010 | ||
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| UniProt code: P84010. |
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| Organism: | |
Ovis aries (Sheep). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis. |
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| Function: | |
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:14527149). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (Probable). {ECO:0000269|PubMed:14527149, ECO:0000305}. |
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| Catalytic activity: | |
Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743, ChEBI:CHEBI:58228; EC=2.1.3.3; Evidence={ECO:0000269|PubMed:14527149}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19515; Evidence={ECO:0000305|PubMed:14527149}; |
| Activity regulation: | |
Negatively regulated by lysine acetylation. {ECO:0000250|UniProtKB:P00480}. |
| Pathway: | |
Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1. {ECO:0000305|PubMed:14527149}. |
| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:14527149}. |
| Subcellular location: | |
Mitochondrion matrix {ECO:0000250|UniProtKB:P00480}. |
| Domain: | |
Residues 88-96, 111-125 and 247-283 form flexible loops whose positions are affected on substrate binding. {ECO:0000303|PubMed:14527149}. |
| Ptm: | |
Acetylation at Lys-89 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. {ECO:0000250|UniProtKB:P00480}. |
| Similarity: | |
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. {ECO:0000269|PubMed:14527149}. |
Annotations taken from UniProtKB at the EBI.