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UniProt functional annotation for P02776 | ||
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| UniProt code: P02776. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}. |
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| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:7547867, ECO:0000269|PubMed:8031770}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:7644496}. |
| Mass spectrometry: | |
[Platelet factor 4]: Mass=7765; Method=Electrospray; Evidence={ECO:0000269|PubMed:7644496}; |
| Mass spectrometry: | |
[Platelet factor 4, short form]: Mass=6033; Method=Electrospray; Note=Short form.; Evidence={ECO:0000269|PubMed:7644496}; |
| Similarity: | |
Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.