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UniProt functional annotation for P61459 | ||
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| UniProt code: P61459. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. {ECO:0000269|PubMed:1763325, ECO:0000269|PubMed:8444860}. |
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| Catalytic activity: | |
Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920, ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96; Evidence={ECO:0000269|PubMed:1465414, ECO:0000269|PubMed:8444860}; |
| Subunit: | |
Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers. {ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:1763325, ECO:0000269|PubMed:7744010, ECO:0000269|PubMed:8444860, ECO:0000269|PubMed:8897596}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:8444860}. Nucleus {ECO:0000269|PubMed:8444860}. Note=Cytoplasmic and/or nuclear. |
| Similarity: | |
Belongs to the pterin-4-alpha-carbinolamine dehydratase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.