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UniProt functional annotation for P22361 | ||
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| UniProt code: P22361. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (PubMed:19289501). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544). {ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:19289501, ECO:0000269|PubMed:30555544}. |
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| Subunit: | |
Binds DNA as a dimer (PubMed:11106484, PubMed:11439029). Heterotetramer with PCBD1; formed by a dimer of dimers (PubMed:10966642). Interacts with PCBD1 (By similarity). Interacts with BHLHE41 (PubMed:30555544). {ECO:0000250|UniProtKB:P20823, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:11106484, ECO:0000269|PubMed:11439029, ECO:0000269|PubMed:30555544}. |
| Subcellular location: | |
Nucleus. |
| Tissue specificity: | |
Liver. |
| Disruption phenotype: | |
Mice are born at less than half of the expected frequency. Neonates are slightly smaller than normal and do not grow normally. After 5 weeks mice weigh only 50 to 60% as much as their littermates. Mice develop non-insulin-dependent diabetes mellitus (NIDDM) 2 weeks after birth. Mice exhibit elevated levels of blood glucose, combined with reduced blood levels of insulin and insulin-like growth factor I (IGFI). Males and females are sterile. {ECO:0000269|PubMed:9566924}. |
| Similarity: | |
Belongs to the HNF1 homeobox family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.