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UniProt functional annotation for Q46389 | ||
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| UniProt code: Q46389. |
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| Organism: | |
Moorella thermoacetica (Clostridium thermoaceticum). |
| Taxonomy: | |
Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Moorella group; Moorella. |
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| Function: | |
Methyltransferase that mediates the transfer of a N5-methyl group of (6S)-methyltetrahydrofolate to the 5- methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein (AcsC/AcsD) in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation. {ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0000269|PubMed:7928975}. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+); Xref=Rhea:RHEA:45200, Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:18608, ChEBI:CHEBI:57453, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.1.1.258; Evidence={ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0000269|PubMed:7928975}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154}; |
| Subunit: | |
Heterohexamer composed of 2 subunits of AcsC, 2 subunits of AcsD and 2 subunits of AcsE. {ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154}. |
| Similarity: | |
Belongs to the vitamin-B12 dependent methionine synthase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.