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UniProt functional annotation for P29459 | ||
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| UniProt code: P29459. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000269|PubMed:1673147, ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:2204066}. |
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| Subunit: | |
Heterodimer with IL12B; disulfide-linked (PubMed:1674604, PubMed:10899108). This heterodimer is known as interleukin IL-12 (PubMed:1674604). Heterodimer with EBI3/IL27B; not disulfide-linked (PubMed:9342359). This heterodimer is known as interleukin IL-35 (PubMed:9342359). {ECO:0000269|PubMed:10899108, ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:9342359}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:9342359}. |
| Induction: | |
(Microbial infection) Down-regulated in response to enterovirus 71 (EV71) infection. {ECO:0000269|PubMed:16548883}. |
| Similarity: | |
Belongs to the IL-6 superfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA59937.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.