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UniProt functional annotation for P00445 | ||
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| UniProt code: P00445. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
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| Catalytic activity: | |
Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; |
| Cofactor: | |
Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds 1 copper ion per subunit.; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Subunit: | |
Homodimer in holo form. In apo form, heterodimer with CCS1. Zinc-binding at 'His-16' of CCS1 and Glu-43 of apo-SOD1 is required for this heterodimerization. {ECO:0000269|PubMed:10026301, ECO:0000269|PubMed:11524675, ECO:0000269|PubMed:8652572}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11500508}. Mitochondrion intermembrane space {ECO:0000269|PubMed:11500508, ECO:0000269|PubMed:22984289}. Note=A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space. |
| Miscellaneous: | |
Present with 519000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the Cu-Zn superoxide dismutase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.