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UniProt functional annotation for P11006 | ||
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| UniProt code: P11006. |
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| Organism: | |
Xenopus laevis (African clawed frog). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. |
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| Function: | |
Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Rapidly inactivates channel catfish herpesvirus (ED(50)=48 uM) over a wide temperature range (PubMed:15193922). Magainins are membrane lytic agents. {ECO:0000269|PubMed:15193922}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin. |
| Similarity: | |
Belongs to the gastrin/cholecystokinin family. Magainin subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.