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UniProt functional annotation for P07385 | ||
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| UniProt code: P07385. |
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| Organism: | |
Cowpox virus (strain Brighton Red) (CPV). |
| Taxonomy: | |
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus. |
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| Function: | |
Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a 'cross-class' interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B. {ECO:0000269|PubMed:1339309, ECO:0000269|PubMed:8034697}. |
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| Subcellular location: | |
Host cytoplasm {ECO:0000305}. |
| Similarity: | |
Belongs to the serpin family. Poxviruses subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.