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UniProt functional annotation for Q94734 | ||
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| UniProt code: Q94734. |
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| Organism: | |
Rhodnius prolixus (Triatomid bug). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera; Cimicomorpha; Reduviidae; Triatominae; Rhodnius. |
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| Function: | |
Heme-based protein that delivers nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also binds tightly to histamine, which is released by the host to induce wound healing. NO release is pH dependent and linked to loop dynamics. {ECO:0000269|PubMed:15157102, ECO:0000269|PubMed:15598503, ECO:0000269|PubMed:20524697, ECO:0000269|PubMed:23133364, ECO:0000269|PubMed:23885811}. |
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| Catalytic activity: | |
Reaction=2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide; Xref=Rhea:RHEA:31367, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16301, ChEBI:CHEBI:16480, ChEBI:CHEBI:17632; EC=1.7.6.1; Evidence={ECO:0000269|PubMed:20524697}; |
| Cofactor: | |
Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000269|PubMed:20524697}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. {ECO:0000269|PubMed:20524697}; |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the salivary glands. |
| Miscellaneous: | |
Superposition of the structures of NP4 in the presence of ammonia or nitrite shows a conformational change of the protein upon NO(2)(-) binding. {ECO:0000269|PubMed:10876239, ECO:0000269|PubMed:11560480, ECO:0000269|PubMed:15157102, ECO:0000269|PubMed:15504026, ECO:0000269|PubMed:22976968}. |
| Similarity: | |
Belongs to the calycin superfamily. Nitrophorin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.