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UniProt functional annotation for P05221 | ||
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| UniProt code: P05221. |
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| Organism: | |
Xenopus laevis (African clawed frog). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. |
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| Function: | |
Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores (PubMed:11684019, PubMed:19055325). Involved in chromatin remodeling, especially during fertilization and early embryonic development (By similarity). May be involved in sperm chromatin decondensation during fertilization (PubMed:17510054). {ECO:0000250|UniProtKB:Q86SE8, ECO:0000269|PubMed:11684019, ECO:0000269|PubMed:17510054, ECO:0000269|PubMed:19055325}. |
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| Biophysicochemical properties: | |
Temperature dependence: Thermostable.; |
| Subunit: | |
Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously. Interacts with the heterotetramer formed by wdr77 and prmt5. {ECO:0000269|PubMed:10745017, ECO:0000269|PubMed:11684019, ECO:0000269|PubMed:19055325, ECO:0000269|PubMed:22009756}. |
| Subcellular location: | |
Nucleus. |
| Ptm: | |
Activated by phosphorylation of multiple serine/threonine residues, along both core and tail domains. The level of phosphorylation gradually increases during egg maturation, reaching an average of 7-10 phosphates per monomer, so that at the time of fertilization the activity of the protein is maximum. {ECO:0000269|PubMed:17510054, ECO:0000269|PubMed:19055325}. |
| Ptm: | |
Methylated by prmt5, yielding both monomethylated and symmetrically dimethylated Arg-192. {ECO:0000269|PubMed:22009756}. |
| Similarity: | |
Belongs to the nucleoplasmin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.