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UniProt functional annotation for P11959 | ||
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| UniProt code: P11959. |
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| Organism: | |
Geobacillus stearothermophilus (Bacillus stearothermophilus). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. |
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| Function: | |
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. |
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| Catalytic activity: | |
Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)- lipoyl-L-lysyl-[protein] + H(+) + NADH; Xref=Rhea:RHEA:15045, Rhea:RHEA-COMP:10474, Rhea:RHEA-COMP:10475, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.8.1.4; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; |
| Subunit: | |
Homodimer. Identified in a complex with PdhC. {ECO:0000269|PubMed:8805537}. |
| Subcellular location: | |
Cytoplasm. |
| Miscellaneous: | |
The active site is a redox-active disulfide bond. |
| Similarity: | |
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.