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UniProt functional annotation for P10802 | ||
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| UniProt code: P10802. |
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| Organism: | |
Azotobacter vinelandii. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Azotobacter. |
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| Function: | |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). |
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| Catalytic activity: | |
Reaction=(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)- N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA; Xref=Rhea:RHEA:17017, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:10478, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:83100, ChEBI:CHEBI:83111; EC=2.3.1.12; |
| Cofactor: | |
Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 3 lipoyl cofactors covalently. {ECO:0000250}; |
| Subunit: | |
Forms a 24-polypeptide structural core with octahedral symmetry. |
| Similarity: | |
Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA30987.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.