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UniProt functional annotation for Q9Q2W5 | ||
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| UniProt code: Q9Q2W5. |
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| Organism: | |
Newcastle disease virus (strain Kansas) (NDV). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Avulavirinae; Orthoavulavirus; Avian orthoavulavirus 1. |
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| Function: | |
Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. {ECO:0000250|UniProtKB:Q91UL0}. |
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| Function: | |
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. {ECO:0000250|UniProtKB:Q91UL0}. |
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| Catalytic activity: | |
Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; Evidence={ECO:0000250|UniProtKB:Q91UL0}; |
| Subunit: | |
Homodimer. Forms homotetramers. Interacts with fusion/F protein. Interacts with host CG-1B; this interaction inhibits viral adsorption and replication rather than internalization. {ECO:0000250|UniProtKB:Q91UL0}. |
| Subcellular location: | |
Virion membrane {ECO:0000250|UniProtKB:Q91UL0}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91UL0}. Host cell membrane {ECO:0000250|UniProtKB:Q91UL0}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91UL0}. |
| Similarity: | |
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.