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UniProt functional annotation for P08165 | ||
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| UniProt code: P08165. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. {ECO:0000269|PubMed:7811729}. |
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| Catalytic activity: | |
Reaction=H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]; Xref=Rhea:RHEA:42312, Rhea:RHEA-COMP:9998, Rhea:RHEA- COMP:9999, ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.18.1.6; Evidence={ECO:0000269|PubMed:7811729}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:10369776}; |
| Pathway: | |
Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:7811729}. |
| Subunit: | |
Monomer. Interacts directly with FDX1. {ECO:0000269|PubMed:10369776, ECO:0000269|PubMed:10998235, ECO:0000269|PubMed:11053423}. |
| Subcellular location: | |
Mitochondrion inner membrane {ECO:0000250|UniProtKB:P48360}; Peripheral membrane protein {ECO:0000305}. |
| Tissue specificity: | |
Detected in adrenal cortex and corpus luteum (at protein level). {ECO:0000269|PubMed:3011431}. |
| Miscellaneous: | |
[Isoform Long]: Represents 10-20% of all adrenodoxin reductase mRNAs and seems to be inactive. {ECO:0000305}. |
| Similarity: | |
Belongs to the ferredoxin--NADP reductase type 1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.