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UniProt functional annotation for Q9SWE5 | ||
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| UniProt code: Q9SWE5. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'- phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine. {ECO:0000269|PubMed:12860978, ECO:0000269|PubMed:16415216}. |
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| Catalytic activity: | |
Reaction=H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D- pantetheine 4'-phosphate; Xref=Rhea:RHEA:16793, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:59458, ChEBI:CHEBI:61723; EC=4.1.1.36; |
| Cofactor: | |
Name=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN per subunit.; |
| Pathway: | |
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 3/5. |
| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:10986463, ECO:0000269|PubMed:12614618}. |
| Tissue specificity: | |
Expressed in roots, shoots, leaves, flowers, developing siliques and seeds with highest expression in seed embryos and phloem. {ECO:0000269|PubMed:10652125}. |
| Induction: | |
By salt stress. {ECO:0000269|PubMed:10652125}. |
| Disruption phenotype: | |
No visible phenotype under normal growth conditions, but homozygous double mutants hal3a-1 and hal3b are embryonic lethal. {ECO:0000269|PubMed:16415216}. |
| Similarity: | |
Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.