PDBsum entry 1dty

Transferase

PDB id: 1dty

Contents

Protein chains

429 a.a. *

Ligands

PLP ×2

Metals

_NA ×4

Waters ×334

* Residue conservation analysis

PDB id:

1dty

Name:

Transferase

Title:

Crystal structure of adenosylmethionine-8-amino-7-oxonanoate aminotransferase with pyridoxal phosphate cofactor.

Structure:

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. Chain: a, b. Ec: 2.6.1.62

Source:

Escherichia coli. Organism_taxid: 562

Biol. unit:

Dimer (from PQS)

Resolution:

2.14Å R-factor: 0.196 R-free: 0.328

Authors:

D.Alexeev,L.Sawyer,R.L.Baxter,M.V.Alexeeva,D.Campopiano

Key ref:

D.Alexeev et al. Crystal structure of adenosylmethionine-8-Amino-7-Oxonanoate aminotransferase with pyridoxal phosphate cofactor. To be published, .

Date:

13-Jan-00 Release date: 18-Feb-00

Protein chains

P12995  (BIOA_ECOLI) -  Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Escherichia coli (strain K12)

Seq: 429 a.a.

Struc: 429 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.6.1.62 - adenosylmethionine--8-amino-7-oxononanoate transaminase.
• Reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4- methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate
• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PLP) matches with 93.75% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site