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UniProt functional annotation for P18910 | ||
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| UniProt code: P18910. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10894551, ECO:0000269|PubMed:15117952}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Ptm: | |
Phosphorylation of the protein kinase-like domain is required for full activation by ANP. {ECO:0000269|PubMed:20977274, ECO:0000269|PubMed:9528788}. |
| Similarity: | |
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}. |
Annotations taken from UniProtKB at the EBI.